Identification and function of genes that increase risk for endometriosis
2019 update:
This project has made some very good progress in 2019, with Jessica Chung providing the expertise from our team to enable
- development of a method to normalise cycle stage effects in endometrium expression data
- developed an interactive R Shiny application where the research group can explore microarray and RNA-seq data with their own parameters
- analysis of endometriosis severity and BMI, lipidomics data, uterine receptivity, and clinical factors that influence repeat surgery.
Project description
Endometriosis is a disorder that affects 5 – 10% of reproductive age women in Australia, causing severe pain and infertility. This project aims to use genomic data to identify candidate genes that increase the risk of endometriosis. We are also investigating mechanisms that cause reduced endometrial receptivity, the association between BMI and endometriosis, and clinical indicators that can predict repeat surgery for endometriosis.
Project collaborators
Prof Peter Rogers, Professor Of Women’s Health Research, Obstetrics and Gynaecology Royal Women’s Hospital/Mercy
Dr Sarah Carson, Research Fellow, Obstetrics And Gynaecology Royal Women’s Hospital/Mercy
Dr Wan Tinn Teh, Clinician, Royal Women’s Hospital & Melbourne IVF
Ms Jessica Chung, Melbourne Bioinformatics
Grant
NHMRC: Identification And Function Of Genes That Increase Risk For Endometriosis (Grant number: 1105321, 2016-2019)