Richard Lupat, Bioinformatician, PeterMac



Walter and Eliza Hall Institute of Medical ResearchCOLLABORATOR
Peter MacCallum Cancer CentreLEAD INSTITUTE
University of MelbourneCOLLABORATOR


PeterMac / WEHI / Melbourne Bioinformatics (University of Melbourne) co-funding


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In September 2018, talented software engineer, Michael Franklin, joined us to work on a new collaborative project between Peter MacCallum Cancer Centre (Richard Lupat and Jason Li), Melbourne Bioinformatics (Daniel Park and Bernard Pope) and WEHI (Evan Thomas). This Portable Pipelines Project (PPP) anticipates the complex needs of cancer researchers as whole genome sequencing (WGS) becomes a routine in research and part of standard clinical evaluation of disease. It is expected that at the conclusion of the project (18 months), Precinct researchers will have access to a modular, portable bioinformatics pipeline system, capable of meeting current and future needs of WGS analysis.

Bench scientists working in cancer genomics are increasingly reliant upon data scientists. Data scientists are able to stay on top of the choice best practice analysis tools, can problem-solve how to maximise access to scarce compute resources and bring their data management and curation discipline which is increasingly required for sharing data for publication, collaboration and reproducibility.

This project aims to produce a modular and robust portable pipeline using common workflow development language to enable it to run on multiple computing platforms without the need to rewrite the workflow to accommodate multiple hardware systems (from local HPC to cloud).

Along the way, it is envisaged that the team will also learn a great deal more about working with containers, workflow development language, different engines such as TOIL and CROMWELL and various compute platforms, and gain the skills required to change pipelines as needed for research problems.

Whilst being developed for whole genome sequencing for cancer research, if it’s successful, in the long term the software should be able to extend to other domains. And this means the team will have developed an extremely useful tool which will be in demand by research teams worldwide.

Project members

Mr Richard Lupat, Bioinformatician, Bioinformatics Consulting Core, PeterMac

Dr Jason Li, Manager, Bioinformatics Consulting Core, PeterMac

Assoc Prof Bernard Pope, Senior Bioinformatician, Melbourne Bioinformatics

Assoc Prof Daniel Park, Platform Lead, Melbourne Bioinformatics

Mr Evan Thomas, HPC Platform, WEHI

Mr Michael Franklin, Research Software Engineer, Melbourne Bioinformatics